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Mechanism and Efficacy
Mecnanism of Action
GLP-1R:
Slows gastric emptying, enhances satiety,and reduces appetite.
GIPR:
Regulates hunger signals in the centralnervous system, further suppresses appetiteand improves energy metabolism.
GCGR:
Promotes glucagon secretion, acceleratesfat and glycogenolysis, and increases basalmetabolic rate.
Indications and Efficacy
Obesity Treatment:
In the Phase II clinical trial, patients in the highest dosegroup (12 mg) lost an average of 24.2% weight after48 weeks, and some patients lost more than 30%.
Metabolic Dysfunction-AssociatedFatty Liver Disease (MASLD):
Retatrutide can reduce liver fat content by 86% and morethan 85% of patients achieve regression of liver steatosis.
Type II Diabetes:
Significantly reduce glycated hemoglobin(HbAlc) andimprove blood sugar control.
Potential Cardiovascular Benefits:
Animal studies have shown that it may indirectly protectcardiovascular health by improving blood pressure andheart function, but further clinical verification is needed.
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